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ICM research/guidelines in progress

Guidelines

NICE guidelines

Sepsis

 

Studies

Diagnosis

METPSDS – microRNA analysis

VAC – Periitoneal cytokines in open abdomens

NOBIS – novel biomarkers

MitoSepsis – mitochondrial function

Prognosis

 PliNOSa – iNOS

ADMA and DDAH II

DYNAMICS:DNA – naked DNA

BNP

Lactate

Copeptin

 

Therapeutics

Sepsis molecules

OASIS – talactoferrin

AB103

ALP

C1-esterase inhibitor

Proglitazone

Sirtuin-1 activator

CytoFab, anti-TNFalpha

Others

DESIRE – dexmedetomidine

Paracetamol

SEREAL – selenium

SISPCT – selenite and PCT guided antimicrobial therapy

Citrulline

Statins

SAILS – statins for ARDS

Steroids

HYPRESS

ADRENAL

Angiotensin in AKI – ASK-IT

Noradrenaline sparing – ATHOS

Heparin in septic shock – HALO

EGDT

ProCESS

ARISE

AGONIST

ProMISe

Fluids

RASP – Ringers v albumin

Pressors and inotropes

Vasopressin v Noradrenaline – VANCS II

Hypertonic saline and terlipressin – HYSATESS-p

DORESEP – renal function and MAP control

Equipment

BIOVISION – impedance

PiCCO-guidance – THEMIS

 

Renal

Cascade haemofiltration

HICORES – High dose CVVHF

SAFBT – selective toxin removal

 

Haematology

ABLE – age of transfused blood in critical illness

 

TBI 

EPO-TBI – erythropoietin and neurological outcome after TBI

 

Therapeutic hypothermia

CASS – mild hypothermia

EUROTHERM 3235 – in traumatic brain injury

 

ECMO

ECMO for refractory septic shock

ICU outcomes

ICON – ICU outcomes – ongoing study since 2006

 

Delirium

HOPE – haloperidol in ICU

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