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| Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events Extracorporeal Membrane Oxygenation Treatment or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial. | 2021 Apr 27 | INSPIRATION Investigators. | JAMA |
| Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9 Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial | 2021 Aug 10 | Zampieri | JAMA |
| Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock. DOREMI | 2021 Aug 5 | Mathew R | N Engl J Med |
| Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. COCA | 2021 Dec 14 | Vallentin MF | JAMA |
| Effect of Out-of-Hospital Sodium Nitrite on Survival to Hospital Admission After Cardiac Arrest: A Randomized Clinical Trial. SNOCAT | 2021 Jan 12 | Kim F | JAMA |
| Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre randomised double-blind placebo-controlled phase 3 trial. CHARLI | 2021 Jan 22 | Dixon B | Lancet Respir Med |
| Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. TTM2 | 2021 Jun 17 | Dankiewicz J | N Engl J Med |
| Postoperative continuous positive airway pressure to prevent pneumonia re-intubation and death after major abdominal surgery (PRISM): a multicentre open-label randomised phase 3 trial. | 2021 Jun 18 | PRISM trial group. | Lancet Respir Med |
| A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis. ATTIRE | 2021 Mar 4 | China L | N Engl J Med |
| Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome. CONFIRM | 2021 Mar 4 | Wong F | N Engl J Med |
| Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial. | 2021 May 25 | Roquilly A | JAMA |
| Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study-a randomized clinical trial. | 2021 Nov | Boh | Intensive Care Med |
| The association between mean arterial pressure and outcomes in patients with cardiogenic shock: insights from the DOREMI trial. | 2021 Oct 1 | Parlow S | Eur Heart J Acute Cardiovasc Care |
| Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial. VAM IHCA | 2021 Oct 26 | Andersen LW | JAMA |
| Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis. | 2021 Oct 7 | Boxhoorn L | N Engl J Med |
| Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial. | 2021 Sep 21 | McNamee JJ | JAMA |
| Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter Rapidly Adaptive Pragmatic Randomized Controlled Trial. | 2021 Sep 27 | Barrett CD | Chest |
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