Top articles 2018

Pantoprazole for Patients at Risk of Gastrointestinal Bleeding in the ICU (SUP-ICU) (Oct 2018) and BottomLine review

Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial (Dec 2018) and BottomLine review

Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome (Dec 2018)

Energy-Dense versus Routine Enteral Nutrition in the Critically Ill (TARGET) (November 2018) and BottomLine review

A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest (August 2018) and BottomLine review

Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial (Lancet July 18) and BottomLine review

Sedation Intensity in the First 48 Hours of Mechanical Ventilation and 180-Day Mortality: A Multinational Prospective Longitudinal Cohort Study. (June2018)

Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial. (June 2018)

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery. (RELIEF) (June 2018)

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. (EOLIA) (May 2018)

Effect of Bag/Mask Ventilation vs Endotracheal Intubation During Cardiopulmonary Resuscitation on Neurological Outcome After Out-of-Hospital Cardiorespiratory Arrest: A Randomized Clinical Trial. (March 2018)

Association of Hypercapnia and Hypercapnic Acidosis With Clinical Outcomes in Mechanically Ventilated Patients With Cerebral Injury (March 2018)

Adjunctive glucocorticoid therapy in patients with septic shock – (ADRENAL) (March 2018)

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock (APROCHSS) Annane’s latest – Mar 2018

Balanced Crystalloids versus Saline in Critically Ill Adults (SMART-MED) (Feb 18)

Balanced Crystalloids versus Saline in Non-Critically Ill Adults  (SALT-ED) (Feb 18)

Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: REDUCE (Feb 2018)

SR and MA of Procalcitonin-Guidance Versus Usual Care for Antimicrobial Management in Critically Ill Patients (Jan 18)

Pooled analysis of higher versus lower blood pressure targets for vasasopressor therapy in septic and vasodilatory shock. (Jan 18)

Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial. (Resus Jan 2018)