ARDS
Ventilation Strategy
Amato MBP et al.‘Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome’. New England Journal of Medicine 338, no. 6 (1998): 347–354.Φ Stewart TE et al.
‘Evaluation of a Ventilation Strategy to Prevent Barotrauma in Patients at High Risk for Acute Respiratory Distress Syndrome’.
Brochard L et al.
‘Tidal Volume Reduction for Prevention of Ventilator-Induced Lung Injury in Acute Respiratory Distress Syndrome. The Multicenter Trail Group on Tidal Volume Reduction in ARDS’.
ARDSNET low Vt – De Campos T et al (BL review)
‘Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. The Acute Respiratory Distress Syndrome Network’.
N Engl J Med 342, no. 18 (2000): 1302–130g.Φ
Eichacker P et al.
Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes.
American Journal of Respiratory and Critical Care Medicine 2002 166: 1510-4
LOV – Meade MO et al.
‘Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial’.
JAMA: The Journal of the American Medical Association 299, no. 6 (13 February 2008):637645. doi:10.1001/jama.299.6.637.
Needham D et al.
‘Lung Protective Mechanical Ventilation and Two Year Survival in Patients with Acute Lung Injury: Prospective Cohort Study’.
BMJ (Clinical Research Ed.) 344 (2012): e2124.Φ
Severity of Hypoxemia and Effect of High-Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome. (Sept) 2017
Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome (Nov 1207)
PEEP
ARDSNET PEEP (ALVEOLI) – Brower R et al. NHLBI/ARDSNET ‘Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome’. The New England Journal of Medicine 351, no. 4 (22 July 2004): 327–336. doi:10.1056/NEJMoa032193. EXPRESS – Mercat A et al. ‘Positive End-Expiratory Pressure Setting in Adults with Acute Lung Injury and Acute Respiratory Distress Syndrome’. JAMA: The Journal of the American Medical Association 299, no. 6 (2008): 646–655.
Goligher EC et al.
Oxygenation response to positive end-expiratory pressure predicts mortality in acute respiratory distress syndrome. A secondary analysis of the LOVS and ExPress trials.
Am J Respir Crit Care Med. 2014 Jul 1;190(1):70–6.
Paralysis
Papazian L et al.
‘Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome’.
The New England Journal of Medicine 363, no. 12 (16 September 2010): 1107–1116. doi:10.1056/NEJMoa1005372.
Steingrub JS et al.
‘Treatment with Neuromuscular Blocking Agents and the Risk of in-Hospital Mortality among Mechanically Ventilated Patients with Severe Sepsis*’.
Critical Care Medicine 42, no. 1 (January 2014): 90–96. doi:10.1097/CCM.0b013e31829eb7c9.
Oscillation
Derdak S et al.
‘High-Frequency Oscillatory Ventilation for Acute Respiratory Distress Syndrome in Adults: A Randomized, Controlled Trial’.
American Journal of Respiratory and Critical Care Medicine 166, no. 6 (15 September 2002): 801–8. doi:10.1164/rccm.2108052.
OSCILLATE – Ferguson ND et al. (BL review)
‘High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome’.
New England Journal of Medicine 368, no. 9 (28 February 2013): 795–805. doi:10.1056/NEJMoa1215554.
OSCAR – Young D et al.(BL review)
‘High-Frequency Oscillation for Acute Respiratory Distress Syndrome’.
New England Journal of Medicine 368, no. 9 (28 February 2013): 806–13. doi:10.1056/NEJMoa1215716.
Sud S et al.
‘High-Frequency Ventilation versus Conventional Ventilation for Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome’.
The Cochrane Database of Systematic Reviews 2 (2013): CD004085. doi:10.1002/14651858.CD004085.pub3.
Prone position
Mancebo J et al. ‘A Multicenter Trial of Prolonged Prone Ventilation in Severe Acute Respiratory Distress Syndrome’. American Journal of Respiratory and Critical Care Medicine 173, no. 11 (2006): 1233–1239. Fernandez R et al. Prone positioning in acute respiratory distress syndrome: a multicenter randomized clinical trial. Intensive Care Medicine 2008; 34: 1487-91 PROSEVA – Guérin C et al. ‘Prone Positioning in Severe Acute Respiratory Distress Syndrome’. The New England Journal of Medicine 368, no. 23 (6 June 2013): 2159–2168. doi:10.1056/NEJMoa1214103.(BL Review) Sud S et al.
Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis.
CMAJ. 2014 Jul 8;186(10):E381–390.
‘The Efficacy and Safety of Prone Positional Ventilation in Acute Respiratory Distress Syndrome: Updated Study-Level Meta-Analysis of 11 Randomized Controlled Trials’.
Critical Care Medicine 42, no. 5 (May 2014): 1252–62. doi:10.1097/CCM.0000000000000122.
Recruitment manoeuvres
Fan E et al. ‘Recruitment Maneuvers for Acute Lung Injury: A Systematic Review’. American Journal of Respiratory and Critical Care Medicine 178, no. 11 (December 2008): 1156–1163. doi:10.1164/rccm.200802-335OC.Steroids
Meduri GU et al. (BL review) Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. JAMA. 1998 Jul 8;280(2):159–65. ARDSNET Steroids – Steinberg K et al. NHLBI/ARDSNET. ‘Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome’. The New England Journal of Medicine 354, no. 16 (20 April 2006): 1671–1684. doi:10.1056/NEJMoa051693 Meduri UG et al. (BL review) ‘Methylprednisolone Infusion in Early Severe ARDS: Results of a Randomized Controlled Trial’. Chest 131, no. 4 (April 2007): 954–963. doi:10.1378/chest.06-2100. Meduri GUet al. Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Medicine 2008; 34 : 61-9 Peter JV et al. Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: metaanalysis. British Medical Journal 2008; 336: 1006-9.Fluid management
ARDSNET FACTT – Wiedemann HP, Wheeler AP et al Comparison of two fluid-management strategies in acute lung injury. New England Journal of Medicine 2006; 354: 2564-75.ECMO
CESAR – Wiedemann HP et al Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. N Engl J Med. 2006 Jun 15;354(24):2564-75 ANZ ECMO – Davies A et al. ‘Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome’. JAMA: The Journal of the American Medical Association 302, no. 17 (4 November 2009): 1888–1895. doi:10.1001/jama.2009.1535. Schmidt M e al. Predicting Survival after Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Failure. The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) Score Am J Respir Crit Care Med. 2014 Jun 1;189(11):1374-82. doi: 10.1164/rccm.201311-2023OC.Pharmacotherapy
BALTI – Perkins GD et al. ‘The Β-Agonist Lung Injury Trial (BALTI): A Randomized Placebo-Controlled Clinical Trial’. American Journal of Respiratory and Critical Care Medicine 173, no. 3 (February 2006): 281–287. doi:10.1164/rccm.200508-1302OC.Davidson WJ et al.
Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis.
Asthma
Stoodley RG et al.
‘The Role of Ipratropium Bromide in the Emergency Management of Acute Asthma Exacerbation: A Metaanalysis of Randomized Clinical Trials’.
Annals of Emergency Medicine 34, no. 1 (July 1999): 8–18.
Nair P et al.
‘Addition of Intravenous Aminophylline to Inhaled beta(2)-Agonists in Adults with Acute Asthma’. The Cochrane Database of Systematic Reviews 12 (2012): CD002742. doi:10.1002/14651858.CD002742.pub2.
Powell C et al.
‘Inhaled Magnesium Sulfate in the Treatment of Acute Asthma’.
The Cochrane Database of Systematic Reviews 12 (2012): CD003898. doi:10.1002/14651858.CD003898.pub5.
Goodacre S et al.
The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma.
Health Technol Assess. 2014 Apr;18(22):1–168. – Bottom line review
Nanchal R et al.
Utilization of mechanical ventilation for asthma exacerbations: analysis of a national database.
Non-ARDS ventilation
PREVENT – Simonis et al.
Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial
JAMA 2018 and BottomLine review
PROBESE (PROVEnet)
(PEEP) with Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients. PROBESE.
COPD
Antón A et al.
‘Predicting the Result of Noninvasive Ventilation in Severe Acute Exacerbations of Patients With Chronic Airflow Limitation’
CHEST Journal 117, no. 3 (1 March 2000): 828. doi:10.1378/chest.117.3.828.
CAOS – Wildman M et al.
‘Implications of Prognostic Pessimism in Patients with Chronic Obstructive Pulmonary Disease (COPD) or Asthma Admitted to Intensive Care in the UK within the COPD and Asthma Outcome Study (CAOS): Multicentre Observational Cohort Study’.
BMJ 335, no. 7630 (1 December 2007): 1132–1132. doi:10.1136/bmj.39371.524271.55.
CAOS prediction – Wildman MJ et al.
Predicting mortality for patients with exacerbations of COPD and Asthma in the COPD and Asthma Outcome Study (CAOS).
Hajizadeh N et al.
What happens to patients with COPD with long-term oxygen treatment who receive mechanical ventilation for COPD exacerbation? A 1-year retrospective follow-up study.
Thorax. 2014 May 14;
Ventilator-associated events
Drakulovic MB et al.
‘Supine Body Position as a Risk Factor for Nosocomial Pneumonia in Mechanically Ventilated Patients: A Randomised Trial’.
Lancet 354, no. 9193 (27 November 1999): 1851–58. doi:10.1016/S0140-6736(98)12251-1
Heyland D et al. (Canadian Critical Care Trials Group)
A randomized trial of diagnostic techniques for ventilator-associated pneumonia.
New England Journal of Medicine 2006; 355: 2619-30
Safdar N et al.
Clinical and economic consequences of ventilator-associated pneumonia: a systematic review.
Critical Care Medicine 2005; 33: 2184-93.
Craven DE et al.
‘Incidence and Outcomes of Ventilator-Associated Tracheobronchitis and Pneumonia’.
The American Journal of Medicine 126, no. 6 (June 2013): 542–549. doi:10.1016/j.amjmed.2012.12.012
SODD/SDD
Silvestri L et al. ‘Selective Decontamination of the Digestive Tract: A Life Saver’. Journal of Hospital Infection 45, no. 3 (July 2000): 185–90. doi:10.1053/jhin.2000.0737. Bonten MJM ‘Selective Digestive Tract Decontamination—will It Prevent Infection with Multidrug-Resistant Gram-Negative Pathogens but Still Be Applicable in Institutions Where Methicillin-Resistant Staphylococcus Aureus and Vancomycin-Resistant Enterococci Are Endemic?’ Clinical Infectious Diseases 43, no. Supplement 2 (2006): S70–S74. Chan EY et al. ‘Oral Decontamination for Prevention of Pneumonia in Mechanically Ventilated Adults: Systematic Review and Meta-Analysis’. BMJ 334, no. 7599 (28 April 2007): 889–889. doi:10.1136/bmj.39136.528160.BE. Dallas J’ Oral Decontamination to Prevent Ventilator-Associated Pneumonia: Is It a Sound Strategy?’ CHEST Journal 135, no. 5 (1 May 2009): 1116. doi:10.1378/chest.08-2757. Panchabhai TS et al. ‘Oropharyngeal Cleansing With 0.2% Chlorhexidine for Prevention of Nosocomial Pneumonia in Critically Ill Patients: An Open-Label Randomized Trial With 0.01% Potassium Permanganate as Control’. CHEST Journal 135, no. 5 (1 May 2009): 1150. doi:10.1378/chest.08-1321. Klompas M et al. ‘Reappraisal of Routine Oral Care With Chlorhexidine Gluconate for Patients Receiving Mechanical Ventilation: Systematic Review and Meta-Analysis’. JAMA Internal Medicine, 24 March 2014. doi:10.1001/jamainternmed.2014.359. SuDDICU again – Price R et al. ‘Selective Digestive or Oropharyngeal Decontamination and Topical Oropharyngeal Chlorhexidine for Prevention of Death in General Intensive Care: Systematic Review and Network Meta-Analysis’. BMJ (Clinical Research Ed.) 348 (2014): g2197.Non-invasive ventilation
GiViTI – Gristina G et al. (Italian Group for the Evaluation of Interventions in Intensive Care Medicine).
‘Noninvasive versus Invasive Ventilation for Acute Respiratory Failure in Patients with Hematologic Malignancies: A 5-Year Multicenter Observational Survey’.
Critical Care Medicine 39, no. 10 (October 2011): 2232–2239. doi:10.1097/CCM.0b013e3182227a27.
Esteban A et al.
Noninvasive positive-pressure ventilation for respiratory failure after extubation.
New England Journal of Medicine 2004; 350: 2542-256.
Peter JV et al.
Effect of non-invasive positive pressure ventilation (NIPPV) on mortality in patients with acute cardiogenic pulmonary oedema: a meta-analysis.
Lancet 2006; 367: 1155-63.
Cochrane – Faria DAS et al.
Non-invasive positive pressure ventilation for acute respiratory failure following upper abdominal surgery
Cochrane reviews 5th October 2015
Ventilation During Surgery
Severgnini P et al. ‘Protective Mechanical Ventilation during General Anesthesia for Open Abdominal Surgery Improves Postoperative Pulmonary Function’. Anesthesiology 118, no. 6(June 2013): 1307–1321. doi:10.1097/ALN.0b013e31829102de. IMPROVE – Futier E et al. A trial of intraoperative low-tidal-volume ventilation in abdominal surgery N Engl J Med. 2013 Aug 1;369(5):428–37. PROVHILO – PROVE collaborators High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. Lancet. 2014 May 30. pii: S0140-6736(14)60416-5. doi: 10.1016/S0140-6736(14)60416-5 Defresne AA et al. Recruitment of lung volume during surgery neither affects the postoperative spirometry nor the risk of hypoxaemia after laparoscopic gastric bypass in morbidly obese patients: a randomized controlled study. Br J Anaesth. 2014 May 15. pii: aeu101Weaning
SPANISH LUNG FAILURE GROUP – Esteban A et al‘
A Comparison of Four Methods of Weaning Patients from Mechanical Ventilation’.
New England Journal of Medicine 332, no. 6 (1995): 345–350.
Upadya A et al.
‘Fluid Balance and Weaning Outcomes’.
Intensive Care Medicine 31, no. 12 (29 September 2005): 1643–1647. doi:10.1007/s00134-005-2801-3.
Burns KE et al.
A meta-analysis of noninvasive weaning to facilitate liberation from mechanical ventilation.
Canadian Journal of Anaesthesia 2006; 53: 305-15.
Cochrane review 2013 – Burns KE et al.
‘Noninvasive Positive-Pressure Ventilation as a Weaning Strategy for Intubated Adults with Respiratory Failure’.
The Cochrane Database of Systematic Reviews 12 (2013): CD004127. doi:10.1002/14651858.CD004127.pub3.
Jubran A et al.
Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial.
JAMA. 2013 Feb 20;309(7):671-7. doi: 10.1001/jama.2013.159.
Burns KE et all.
Noninvasive positive pressure ventilation as a weaning strategy for intubated adults with respiratory failure
Cochrane Database Syst Rev. 2010 Aug 4;(8):CD004127. doi: 10.1002/14651858.CD004127.pub2.
‘Prolonged Mechanical Ventilation in a Respiratory-Care Setting: A Comparison of Outcome between Tracheostomized and Translaryngeal Intubated Patients’.
IMPROVe (planned) – Bissett BM et al.
‘Protocol: Inspiratory Muscle Training for Promoting Recovery and Outcomes in Ventilated Patients (IMPROVe): A Randomised Controlled Trial’.
Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial.
JAMA. 2013 Feb 20;309(7):671-7. doi: 10.1001/jama.2013.159.
Blackwood B
Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically illadult patients.
Cochrane Database Syst Rev. 2014 Nov 6;11:CD006904. doi: 10.1002/14651858.CD006904.pub3.
Tracheostomy
Bouderka MA et al.
Early tracheostomy versus prolonged endotracheal intubation in severe head injury.
Blot F et al.
Siempos II et al.
Effect of early versus late or no tracheostomy on mortality of critically ill patients receiving mechanical ventilation: a systematic review and meta-analysis.
Lancet Respir Med. 2014 Jun 26;
Sedation and ventilation
ABC – Girard TD et al.
Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial.
Lancet 2008; 371: 126-34.
Pneumonia
Salluh JI et al.
The role of corticosteroids in severe community-acquired pneumonia: a systematic review.
Critical Care 2008; 12: R76
Snijders D et al
‘Efficacy of Corticosteroids in Community-Acquired Pneumonia: A Randomized Double-Blinded Clinical Trial’.
American Journal of Respiratory and Critical Care Medicine 181, no. 9 (1 May 2010): 975–982. doi:10.1164/rccm.200905-0808OC.
Meijvis SCA et al.
‘Dexamethasone and Length of Hospital Stay in Patients with Community-Acquired Pneumonia: A Randomised, Double-Blind, Placebo-Controlled Trial’.
Lancet 377, no. 9782 (11 June 2011): 2023–2030. doi:10.1016/S0140-6736(11)60607-7.
Sligl WI et al
‘Macrolides and Mortality in Critically Ill Patients with Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis*’.
Critical Care Medicine 42, no. 2 (February 2014): 420–432. doi:10.1097/CCM.0b013e3182a66b9b.
Torres A et al.
Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial.
JAMA. 2015 Feb 17;313(7):677-86. doi: 10.1001/jama.2015.88.
Blum CA et al.
Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial.
Lancet. 2015 Jan 16. pii: S0140-6736(14)62447-8. doi: 10.1016/S0140-6736(14)62447-8.
Corticosteroids for pneumonia – Cochrane review (and link to PSI calculator) (Dec 17)
Pulmonary embolism
PISA-PED – Miniati M et al.
‘Accuracy of Clinical Assessment in the Diagnosis of Pulmonary Embolism’.
American Journal of Respiratory and Critical Care Medicine 159, no. 3 (1999): 864–71.
Konstantinides S et al.
‘Heparin plus Alteplase Compared with Heparin Alone in Patients with Submassive Pulmonary Embolism’.
New England Journal of Medicine 347, no. 15 (2002): 1143–50.
Wan, S.
‘Thrombolysis Compared With Heparin for the Initial Treatment of Pulmonary Embolism: A Meta-Analysis of the Randomized Controlled Trials’.
Circulation 110, no. 6 (26 July 2004): 744–49. doi:10.1161/01.CIR.0000137826.09715.9C.
Tapson VF
‘Acute Pulmonary Embolism’.
New England Journal of Medicine 358, no. 10 (2008): 1037–52.
Kuo WT et al
‘Catheter-Directed Therapy for the Treatment of Massive Pulmonary Embolism: Systematic Review and Meta-Analysis of Modern Techniques’.
Journal of Vascular and Interventional Radiology: JVIR 20, no. 11 (November 2009): 1431–40. doi:10.1016/j.jvir.2009.08.002.
Kakkar AK e al.
‘Low-Molecular-Weight Heparin and Mortality in Acutely Ill Medical Patients’.
New England Journal of Medicine 365, no. 26 (29 December 2011): 2463–72. doi:10.1056/NEJMoa1111288.
MOPETT – Sharifi M et al.
‘Moderate Pulmonary Embolism Treated with Thrombolysis (from the “MOPETT” Trial)’.
The American Journal of Cardiology 111, no. 2 (15 January 2013): 273–77. doi:10.1016/j.amjcard.2012.09.027.
Kline J et al
‘Randomized trial of tenecteplase or placebo with low molecular weight heparin for acute submassive PE: assessment of patient-orientated cardiopulmonary outcomes at three months’.
Journal of the American College of Cardiology 61, no. 10 (March 2013): E2074. doi:10.1016/S0735-1097(13)62074-4.
TOPCOAT – Kline et al.
‘Treatment of Submassive Pulmonary Embolism with Tenecteplase or Placebo: Cardiopulmonary Outcomes at 3 Months: Multicenter Double-Blind, Placebo-Controlled Randomized Trial’.
PEITHO – Meyer GEV et al.
‘Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism’.
The New England Journal of Medicine 370, no. 15 (10 April 2014): 1402–11. doi:10.1056/NEJMoa1302097.
Chatterjee S et al.
‘Thrombolysis for Pulmonary Embolism and Risk of All-Cause Mortality, Major Bleeding, and Intracranial Hemorrhage: A Meta-Analysis’.
JAMA: The Journal of the American Medical Association 311, no. 23 (18 June 2014): 2414–21. doi:10.1001/jama.2014.5990.
Nitric oxide
Adhikari NK et al.
Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis.
British Medical Journal 2007; 334: 779-86
Adhikari NKJ et al.
‘Inhaled Nitric Oxide Does Not Reduce Mortality in Patients with Acute Respiratory Distress Syndrome regardless of Severity: Systematic Review and Meta-Analysis*’.
Critical Care Medicine 42, no. 2 (February 2014): 404–412. doi:10.1097/CCM.0b013e3182a27909.
Extubation
Fan T et al.Prophylactic administration of parenteral steroids for preventing airway complications after extubation in adults:meta-analysis of randomised placebo controlled trials.
British Medical Journal 2008; 337: 1088-91
Roberts RJ et al,
‘Corticosteroids for Prevention of Postextubation Laryngeal Edema in Adults’.
The Annals of Pharmacotherapy 42, no. 5 (May 2008): 686–691. doi:10.1345/aph.1K655.
Markovitz BP et al
‘Corticosteroids for the Prevention and Treatment of Post Extubation Stridor in Neonates, Children and Adults’.
The Cochrane Database of Systematic Reviews no. 2 (2008): doi:10.1002/14651858.CD001000.pub2.
Semler MW et al.
Randomized Trial of Apneic Oxygenation during Endotracheal Intubation of the Critically Ill.
Am J Respir Crit Care Med. 2016 Feb 1;193(3):273-80. doi: 10.1164/rccm.201507-1294OC.
Influenza
Boots RJ et al.
‘Experience with High Frequency Oscillation Ventilation during the 2009 H1N1 Influenza Pandemic in Australia and New Zealand’.
Anaesthesia and Intensive Care 39, no. 5 (September 2011): 837–846.
Zangrillo A et al.
‘Extracorporeal Membrane Oxygenation (ECMO) in Patients with H1N1 Influenza Infection: A Systematic Review and Meta-Analysis Including 8 Studies and 266 Patients Receiving ECMO’.
Critical Care (London, England) 17, no. 1 (13 February 2013): R30. doi:10.1186/cc12512.Napolitano LM et al.Critically Ill Patients With Influenza A(H1N1)pdm09 Virus Infection in 2014
JAMA: The Journal of the American Medical Association, 24 February 2014. doi:10.1001/jama.2014.2116.
Heliox
Colebourn CL at al.
Use of helium-oxygen mixture in adult patients presenting with exacerbations of asthma and chronic obstructive pulmonary disease: a systematic review.
Obesity
Marik PE and Desai H.
‘Characteristics of Patients with the “Malignant Obesity Hypoventilation Syndrome” Admitted to an ICU’.
TRALI
Marik, Paul E., and Howard L. Corwin.
‘Acute Lung Injury Following Blood Transfusion: Expanding the Definition:’
Critical Care Medicine 36, no. 11 (November 2008): 3080–3084. doi:10.1097/CCM.0b013e31818c3801.
Hébert PC
‘A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care’.
New England Journal of Medicine 340, no. 6 (1999): 409–417.
Haematological malignancy
GiViTI – Gristina GR et al (Italian Group for the Evaluation of Interventions in Intensive Care Medicine).
‘Noninvasive versus Invasive Ventilation for Acute Respiratory Failure in Patients with Hematologic Malignancies: A 5-Year Multicenter Observational Survey’.
Critical Care Medicine 39, no. 10 (October 2011): 2232–2239. doi:10.1097/CCM.0b013e3182227a27.
Physiotherapy
Schweickert WD
Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial.
Lancet. 2009 May 30;373(9678):1874-82. doi: 10.1016/S0140-6736(09)60658-9.
Interventions to improve the physical function of ICU survivors: a systematic review.
Chest. 2013 Nov;144(5):1469-80. doi: 10.1378/chest.13-0779.
.
High-flow humidified oxygen
Frat J-P et al.
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.