Definitions
ADQI – Bellomo R. Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the second International Consensus Conference of the Acute Dialysis Quality Initiative Group.Crit Care. 2004 Aug;8(4):R204-12. Epub 2004 May 24.
AKIN – Mehta R et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31.
Lakhal K et al. Acute Kidney Injury Network definition of contrast-induced nephropathy in the critically ill: incidence and outcome. J Crit Care. 2011 Dec;26(6):593-9. doi: 10.1016/j.jcrc.2011.05.010. Epub 2011 Jul 6.
Renal support
Bouman C. et al.
‘Effects of Early High-Volume Continuous Venovenous Hemofiltration on Survival and Recovery of Renal Function in Intensive Care Patients with Acute Renal Failure: A Prospective, Randomized Trial’.
Critical Care Medicine 30, no. 10 (2002): 2205–2211.
DO-RE-MI – Kindgen-Milles D et al.
‘Study Protocol: The Dose Response Multicentre International Collaborative Initiative (DO-RE-MI)’.
Critical Care 9, no. 4 (2005): R396–R406.
HEMODIAFE – Vinsonneau C et al.
‘Continuous Venovenous Haemodiafiltration versus Intermittent Haemodialysis for Acute Renal Failure in Patients with Multiple-Organ Dysfunction Syndrome: A Multicentre Randomised Trial’.
Lancet 368, no. 9533 (29 July 2006): 379–385. doi:10.1016/S0140-6736(06)69111-3
Schiffl H.
‘Renal Recovery from Acute Tubular Necrosis Requiring Renal Replacement Therapy: A Prospective Study in Critically Ill Patients’.
Nephrology Dialysis Transplantation 21, no. 5 (2006): 1248
John S and Eckardt KU
‘Renal Replacement Strategies in the ICU’.
Chest 132, no. 4 (October 2007): 1379–1388. doi:10.1378/chest.07-0167.
RENAL – Bellomo R et al.
‘Intensity of continuous renal replacement in Critically Ill Patients’.
New England Journal of Medicine 359, no. 1 (July 2008): 7–20. doi:10.1056/NEJMoa0802639
VA/NIH (ARFTN) – Palevsky PM et al.
‘Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury’.
N Engl J Med 359, no. 1 (2008): 7–20. Wessex ICS BL review
Pannu NS et al.
‘Renal Replacement Therapy in Patients with Acute Renal Failure’.
JAMA: The Journal of the American Medical Association 299, no. 7 (2008): 793.
Tolwani AJ et al.
‘Standard versus High-Dose CVVHDF for ICU-Related Acute Renal Failure’.
Journal of the American Society of Nephrology 19, no. 6 (March 2008): 1233–1238. doi:10.1681/ASN.2007111173
Payen D et al.
‘Impact of Continuous Venovenous Hemofiltration on Organ Failure during the Early Phase of Severe Sepsis: A Randomized Controlled Trial*’.
Critical Care Medicine 37, no. 3 (March 2009): 803–810. doi:10.1097/CCM.0b013e3181962316.
IDEAL – Cooper BA et al.
A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis.
N Engl J Med 2010; 363:609-619
IVOIRE – Joannes-Boyau O et al.
‘High-Volume versus Standard-Volume Haemofiltration for Septic Shock Patients with Acute Kidney Injury (IVOIRE Study): A Multicentre Randomized Controlled Trial’.
Intensive Care Medicine 39, no. 9 (September 2013): 1535–46. doi:10.1007/s00134-013-2967-z.
CONVINT – Schefold JC et al.
The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): a prospective randomized controlled trial.
AKIKI group – Gaudry S et al.
Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit.
ELAIN -Zarbock et al.
Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury
IDEAL-ICU – Barbar et al.
Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis
Christiansen S et al.
Timing of renal replacement therapy and long-term risk of chronic kidney disease and death in intensive care patients with acute kidney injury.
Bicarbonate
Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial (Lancet July 18) and BottomLine review
Diuretics and fluid balance
Bagshaw SM
Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis.
Crit Care Resusc. 2007 Mar;9(1):60–8.
FACTT AKI – Grams ME.
Fluid balance, diuretic use, and mortality in acute kidney injury.
Clin J Am Soc Nephrol. 2011 May;6(5):966–73.
Payen D et al.
A positive fluid balance is associated with a worse outcome in patients with acute renal failure.
Crit Care. 2008;12(3):R74.
Bouchard J et al.
Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury.
Kidney Int. 2009 Aug;76(4):422–7.
SPARK protocol – Bagshaw SM et al.
The SPARK Study: a phase II randomized blinded controlled trial of the effect of furosemide in critically ill patients with early acute kidney injury.
Trials. 2010;11:50.
Legrand M, Payen D.
Understanding urine output in critically ill patients.
Ann Intensive Care. 2011;1(1):13.
Teixeira C et al.
Fluid balance and urine volume are independent predictors of mortality in acute kidney injury.
Crit Care. 2013;17(1):R14.
Renal protection
Bellomo et al.
Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group
Lancet. 2000 Dec 23-30;356(9248):2139-43. BL Review
Chen HH et al.
‘Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure with Renal Dysfunction: The ROSE Acute Heart Failure Randomized Trial’.
Contrast injury
Tepel M et al.
Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine.
N Engl J Med. 2000 Jul 20;343(3):180-4.
Tepel M
Preventing nephropathy induced by contrast medium.
N Engl J Med. 2006 Jan 26;354(4):379-86
Solomon R et al.
Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents.
N Engl J Med. 1994 Nov 24;331(21):1416–20.
Marenzi G et al.
The prevention of radiocontrast-agent-induced nephropathy by hemofiltration.
N Engl J Med. 2003 Oct 2;349(14):1333–40.
Merten GJ et al.
Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.
JAMA. 2004 May 19;291(19):2328–34.
Marenzi G et al.
N-acetylcysteine and contrast-induced nephropathy in primary angioplasty.
Lakhal K et al.
Acute Kidney Injury Network definition of contrast-induced nephropathy in the critically ill: incidence and outcome. J Crit Care. 2011 Dec;26(6):593-9. doi: 10.1016/j.jcrc.2011.05.010. Epub 2011 Jul 6. ACT Acetylcysteine for prevention of renal outcomes in patients undergoing coronary and peripheral vascular angiography: main results from the randomized Acetylcysteine for Contrast-induced nephropathy Trial (ACT). Circulation. 2011 Sep 13;124(11):1250–9 PRESERVE protocol – Weisbord SD et al. Prevention of contrast-induced AKI: a review of published trials and the design of the prevention of serious adverse events following angiography (PRESERVE) trial. Clin J Am Soc Nephrol. 2013 Sep;8(9):1618–31.Valette et al.
Sodium Bicarbonate Versus Sodium Chloride for Preventing Contrast-Associated Acute Kidney Injury in Critically Ill Patients: A Randomized Controlled Trial
Haem-related AKI - rhabdomyolysis
PICARD – Mehta RL et al.
Diuretics, mortality, and nonrecovery of renal function in acute renal failure.
Hatamizadeh P et al.
Epidemiologic aspects of the Bam earthquake in Iran: the nephrologic perspective.
Brown CVR et al.
Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference?
Mikkelsen TS and Toft P.
Prognostic value, kinetics and effect of CVVHDF on serum of the myoglobin and creatine kinase in critically ill patients with rhabdomyolysis.
Melli G et al.
Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine (Baltimore).