INTERACT2 – Anderson CS, et al.‘Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage’. New England Journal of Medicine 368, no. 25 (20 June 2013): 2355–2365. doi:10.1056/NEJMoa1214609.
Hypovolaemic shock
CRISTAL – Annane, Djillali et al. ‘Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock: The CRISTAL Randomized Trial’. JAMA 310, no. 17 (6 November 2013): 1809. doi:10.1001/jama.2013.280502.
Sepsis
SSC – Dellinger R et al. ‘Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock’. Critical Care Medicine 41, no. 2 (February 2013): 580–637. doi:10.1097/CCM.0b013e31827e83af.
Respiratory
Ferguson, Niall D et al. ‘High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome’. New England Journal of Medicine 368, no. 9 (28 February 2013): 795–805. doi:10.1056/NEJMoa1215554.
OSCAR – Young D et al. ‘High-Frequency Oscillation for Acute Respiratory Distress Syndrome’. New England Journal of Medicine 368, no. 9 (28 February 2013): 806–813. doi:10.1056/NEJMoa1215716.
IMPROVE – Futier E, et al. ‘A Trial of Intraoperative Low-Tidal-Volume Ventilation in Abdominal Surgery’. New England Journal of Medicine 369, no. 5 (August 2013): 428–437. doi:10.1056/NEJMoa1301082.
PROSEVA – Guérin C et al. ‘Prone Positioning in Severe Acute Respiratory Distress Syndrome’. New England Journal of Medicine 368, no. 23 (6 June 2013): 2159–2168. doi:10.1056/NEJMoa1214103.
Infection
REDUCE MRSA – Huang SS et al. ‘Targeted versus Universal Decolonization to Prevent ICU Infection’. New England Journal of Medicine 368, no. 24 (13 June 2013): 2255–2265. doi:10.1056/NEJMoa1207290.
Therapeutic Hypothermia
TTM – Nielsen N et al. ‘Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest’. New England Journal of Medicine 369, no. 23 (5 December 2013): 2197–2206. doi:10.1056/NEJMoa1310519.
Nutrition/GIT
Reignier, Jean. ‘Effect of Not Monitoring Residual Gastric Volume on Risk of Ventilator-Associated Pneumonia in Adults Receiving Mechanical Ventilation and Early Enteral Feeding: A Randomized Controlled Trial’. JAMA 309, no. 3 (16 January 2013): 249. doi:10.1001/jama.2012.196377.
Van Nood et al. ‘Duodenal Infusion of Donor Feces for Recurrent Clostridium Difficile’. New England Journal of Medicine 368, no. 5 (31 January 2013): 407–415. doi:10.1056/NEJMoa1205037.
Villanueva C et al. ‘Transfusion Strategies for Acute Upper Gastrointestinal Bleeding’. New England Journal of Medicine 368, no. 1 (3 January 2013): 11–21. doi:10.1056/NEJMoa1211801.
