2020 Articles

  1. Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial MIDAS (ICM Sep 2020) BottomLine review
  2. Effect of Ascorbic Acid Corticosteroids and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial. (JAMA Aug 2020)
  3. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international RCT (Lancet Jun 2020)
  4. Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome. LOCO-2 (NEJM Mar 2020) BottomLine review
  5. Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients NONSEDA (NEJM Feb 2020) BottomLine review
  6. Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension. 65 Trial (JAMA Feb 2020) BottomLine review
  7. Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation PEPTIC (JAMA Jan 2020) and Nutshell
  8. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock. VITAMINS (JAMA Jan 2020) BottomLine review and Nutshell
  9. Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-deficient Patients VIOLET (NEJM Dec 2019) BottomLine review