High flow humidified nasal oxygen for respiratory failure has been gaining popularity both in adult and paediatric care in recent years. A number of studies have shown promising results. Announced last year but published this month, FLORALI was a multicenter, sealed randomization, pragmatic RCT with a well-defined study protocol, performed in more than 20 ICUs in France and …
ProMISe, the third of the trials examining goal-directed therapy in early septic shock (neatly compared by Bottom Line), was a large pragmatic parallel RCT at 56 hospitals in England published last month. Patients with SIRS and refractory hypotension OR hypoperfusion who had already had antibiotics were subjected either to the Rivers-style protocol below or to ‘standard care’. …
LITFL Wessex ICS BottomLine Emcrit Thinking Critical Care