Thrombolysis for which PE patients – time to decide?

Chatterjee’s MA after the recent swathe of studies suggests using thrombolysis (full dose) in PE all-comers results in less mortality and fewer recurrences even though bleeding occurs much more frequently (NNH 18). Disability and quality of life might be revealing but is rarely reported (re bleeding but staying alive). If restricted to the under 65s then it’s safer. Time to make up your mind – particularly about the younger patients with signs of right heart compromise!