Proning in ICU is 40 years old now. Meta-analyse 11 high-quality studies in a thorough manner (including blinding to authors!) and it appears strikingly good, with an NNT of 11 – definitely better than protective ventilation alone. Do it in the severely hypoxic (P/F <100 mmHg), do it early (within 72 hours), do it for …
Surely statins are useful for something on the ICU?
July 25, 2014
Recent articles on statins for ARDS treatment, VAP treatment and COPD excerbation prevention have all been disappointing. In the lab they are anti-inflammatory, protect coagulation pathways, and inhibit micro-organisms. On the unit there have been suggestions that they prevent the onset of, and reduce mortality in, severe infections and sepsis, but this has been difficult to replicate in …
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