Narrowing down the TRICC concept to septic shock patients, the TRISS trial looked at a transfusion trigger of 7 g/dl or 9 g/dl, using leuco-depleted blood, for the first 90 days of admission. Multi-centre, parallel-grouped and sensibly powered (over 1000 patients), they achieved good separation of Hb values. No mortality difference at 90 days. No greater ischaemic …
This 2 by 2 study looking at both Epo and transfusion triggers in closed TBI makes interesting reading and re-reading. Although large outcome benefit levels were sought (20%) there was no difference in neurological outcome (or mortality, ARDS, infection rate) between Epo and placebo or between a transfusion trigger of 7 and 10. Nor did Epo seem …
LITFL Wessex ICS BottomLine Emcrit