Talk of the town

WHO and WHA – Recognizing Sepsis as a Global Health Priority: summary of the summary

  1. 6 million deaths/year, most of which are preventable.
  2. Sepsis =
    1. syndromic response to infection and the final common pathway to death from most infectious diseases.
    2. most vital indication for the responsible use of effective antimicrobials for human health.
  3. Urgent need to:
    1. implement and promote measures for prevention; childbirth, surgery, sanitation, nutrition, clean water.
    2. implement national immunization programmes urgently.
    3. improve training of health care professionals and laypeople – time-critical action
    4. promote research (by UN Member States )
    5. raise and encourage public awareness – use the term ‘sepsis’ more often! World sepsis day = September 13th.
    6. develop integrated approaches to the prevention and clinical management of sepsis (and survivor care)
    7. apply and improve the ICD system to establish the prevalence, and development of epidemiologic surveillance systems.


The Global Sepsis Alliance identifies key priorities as:

  1. achieving adequate documentation of sepsis in the global and national disease statistics and reports,
  2. encourage the development of national action plans for sepsis,
  3. fostering quality improvement initiatives on all levels of care and for all health care settings
  4. collaborating with governmental and nongovernmental institutions and bodies that arefocused on strengthening health systems and improving patient safety.


Recent ICM trials/studies – updated 17/9/17

  1. Severity of Hypoxemia and Effect of High-Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome. (Sept)
  2. The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis. (August)

  3. The impact of disability in survivors of critical illness. (August)
  4. Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest – An RCT (July)

  5. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. (June) and the BottomLine summary
  6. The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience. ((June)
  7. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock. (September)
  8. Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis. (June)
  9. Discriminative Accuracy of Physician and Nurse Predictions for Survival and Functional Outcomes 6 Months After an ICU Admission (June)
  10. Angiotensin II for the Treatment of Vasodilatory Shock. (August)
  11. Favorable Neurocognitive Outcome with Low Tidal Volume Ventilation after Cardiac Arrest. (May)
  12. Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock. (April)
  13. Sodium Bicarbonate Versus Sodium Chloride for Preventing Contrast-Associated Acute Kidney Injury in Critically Ill Patients:an RCT (April)
  14. Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: An RCT. (Apirl)

Recent FOAMcc selection – updated 17/9/17

Recent guidelines

 Other recent ICMWK posts

Updated 14/3/17

Severe traumatic brain injury reguidelined

Guidelines for the management of severe traumatic brain injury Brain trauma foundation: 4th edition, 2016   This is a brief summary and some of the wording is changed for brevity, hopefully without too much loss of accuracy. Although not explicitly stated on the guidelines, ‘Severe brain injury’ is generally defined as a brain injury resulting …

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Sepsis 3: rise of the SOFA

Sepsis remains a syndrome without a validated criterion or standard diagnostic test but increasingly comprehensive data sets are making it easier to test validity of  potential criteria. The current instalment of this work in progress has refined the definition of sepsis in light of recent analyses and opinion. Sepsis is life-threatening organ dysfunction caused by a dysregulated …

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