Trauma and burns key papers


Bickell WH et al.

‘Immediate versus Delayed Fluid Resuscitation for Hypotensive Patients with Penetrating Torso Injuries’.

The New England Journal of Medicine 331, no. 17 (27 October 1994): 1105–1109. doi:10.1056/NEJM199410273311701.The Bottom Line review


CRASH – Roberts I et al.

‘Effect of Intravenous Corticosteroids on Death within 14 Days in 10008 Adults with Clinically Significant Head Injury (MRC CRASH Trial): Randomised Placebo-Controlled Trial’.

Lancet 364, no. 9442 (9 October 2004): 1321–1328. doi:10.1016/S0140-6736(04)17188-2. Wessex ICS Bottom line review


CRASH-2  Shakur H et al.

‘Effects of Tranexamic Acid on Death, Vascular Occlusive Events, and Blood Transfusion in Trauma Patients with Significant Haemorrhage (CRASH-2): A Randomised, Placebo-Controlled Trial’.

Lancet 376, no. 9734 (3 July 2010): 23–32. doi:10.1016/S0140-6736(10)60835-5.


HIPOLYTE – Roquilly A et al.

‘Hydrocortisone Therapy for Patients with Multiple Trauma: The Randomized Controlled HYPOLYTE Study’.

JAMA: The Journal of the American Medical Association 305, no. 12 (23 March 2011): 1201–1209. doi:10.1001/jama.2011.360. 


MATTERS – Morrison J et al.

‘Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study’.

Archives of Surgery (Chicago, Ill.: 1960) 147, no. 2 (February 2012): 113–119. doi:10.1001/archsurg.2011.287.

PROPPR – Holcomb JB
Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.

JAMA. 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12 Bottom Line review


Greenhalgh DG et al.

‘American Burn Association Consensus Conference to Define Sepsis and Infection in Burns’.

Journal of Burn Care & Research: Official Publication of the American Burn Association 28, no. 6 (December 2007): 776–90. doi:10.1097/BCR.0b013e3181599bc9.

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