Narrowing down the TRICC concept to septic shock patients, the TRISS trial looked at a transfusion trigger of 7 g/dl or 9 g/dl, using leuco-depleted blood, for the first 90 days of admission. Multi-centre, parallel-grouped and sensibly powered (over 1000 patients), they achieved good separation of Hb values. No mortality difference at 90 days. No greater ischaemic …
Hypothesizing that the determinants of death within 30 days of admission to ICU are different to those for death after 90 days, Garland et al looked at a Canadian 11 ICU registry. We’re familiar with survival curves levelling to population baseline rate after a few months (if you can make it 3 months it’s almost like it …
In this Scottish national audit project a single NEWS score of >8 in the presence of sepsis predicted a >30% chance of ICU admission or dying within 30 days. Interesting from a triage perspective but how about adding the power of a single lactate of more than 2.0 to decide who with sepsis you really should …
LITFL Wessex ICS BottomLine St Emlyns Emcrit