↑ Return to Key papers

Resp table

 


ARDS


 


 



Ventilation Strategy


 


 

Eichacker
P et al.

Meta-analysis of acute lung
injury and acute respiratory distress syndrome trials testing low tidal
volumes.

American Journal of Respiratory and Critical Care Medicine 2002 166: 1510-4

Needham D
et al.

‘Lung Protective Mechanical Ventilation and Two Year
Survival in Patients with Acute Lung Injury:
 Prospective Cohort Study’.

BMJ (Clinical Research Ed.) 344 (2012): e2124.

Amato MBP
et al.

‘Effect of a Protective-Ventilation Strategy on
Mortality in the Acute Respiratory Distress Syndrome’.

New England Journal of Medicine 338, no. 6 (1998): 347–354.

Meade MO
et al.

‘Ventilation Strategy Using Low Tidal Volumes,
Recruitment Maneuvers, and High Positive End Expiratory Pressure for
Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized
Controlled Trial’.

JAMA: The
Journal of the American Medical Association 299, no. 6 (13
February 2008):637645. doi:10.1001/jama.299.6.637.

ARDSNET – De
Campos T et al

Ventilation with Lower Tidal Volumes as Compared
with Traditional Tidal Volumes for Acute Lung Injury and the Acute
Respiratory Distress Syndrome. The Acute Respiratory Distress Syndrome
Network
’.

N Engl J
Med 342, no. 18 (2000): 1302–130g.



Paralysis


 


 

Papazian L
et al.

‘Neuromuscular Blockers in Early Acute Respiratory
Distress Syndrome’.

2010):
1107–1116. doi:10.1056/NEJMoa1005372.

Steingrub
JS et al.

‘Treatment with Neuromuscular Blocking Agents and
the Risk of in-Hospital Mortality among Mechanically Ventilated Patients
with Severe Sepsis*’.

Critical Care Medicine 42, no. 1 (January 2014): 90–96. doi:10.1097/CCM.0b013e31829eb7c9.


PEEP


 


 


ARDSNET
PEEP
 – Brower
R et al. NHLBI/ARDSNET



‘Higher versus Lower Positive End-Expiratory
Pressures in Patients with the Acute Respiratory Distress
 Syndrome’.


The New
England Journal of Medicine
 351, no. 4 (22 July 2004): 327–336. doi:10.1056/NEJMoa032193.


EXPRESS 
– Mercat A
et al.



‘Positive End-Expiratory Pressure Setting in Adults
with Acute Lung Injury and Acute Respiratory Distress Syndrome’.
 


JAMA: The
Journal of the American Medical Association
 299, no. 6 (2008): 646–655.


Prone
position


 


 


PROSEVA
 – Guérin
C et al.



‘Prone Positioning in Severe Acute Respiratory
Distress Syndrome’
.


The New
England Journal of Medicine
 368, no. 23 (6 June 2013): 2159–2168. doi:10.1056/NEJMoa1214103.

Mancebo J
et al.



‘A Multicenter Trial of Prolonged Prone Ventilation
in Severe Acute Respiratory Distress Syndrome’.


American
Journal of Respiratory and Critical Care Medicine
 173, no. 11 (2006): 1233–1239.


Fernandez
R  et al.



Prone positioning in acute respiratory distress
syndrome: a multicenter randomized clinical trial.


Intensive
Care Medicine 2008; 34: 1487-91

 



Recruitment manoeuvres


 


 


Fan E et
al.


Recruitment Maneuvers for Acute Lung Injury: A
Systematic Review
.


American
Journal of Respiratory and Critical Care Medicine 178, no. 11 (December
2008): 1156–1163. doi:10.1164/rccm.200802-335OC.


Steroids


 


 


ARDSNET
Steroids
 –
Steinberg K et al.  NHLBI/ARDSNET.



‘Efficacy and Safety of Corticosteroids for
Persistent Acute Respiratory Distress Syndrom
e’.


The New
England Journal of Medicine
 354, no. 16 (20 April 2006): 1671–1684. doi:10.1056/NEJMoa051693

Meduri GU,
Marik PE, Chrousos GP, Pastores SM, Arlt W et al.



Steroid treatment in ARDS: a critical appraisal of
the ARDS network trial and the recent literature.

Intensive
Care Medicine 2008; 34 : 61-9

Peter JV
et al

.Corticosteroids in the prevention and treatment of
acute respiratory distress syndrome (ARDS) in adults: metaanalysis.

British
Medical Journal 2008; 336: 1006-9.

Salluh JI
et al.



The role of corticosteroids in severe
community-acquired pneumonia: a systematic review.

Critical
Care 2008; 12: R76


Fluid
management


 


 


ARDSNET
FACTT
 –
Wiedemann HP, Wheeler AP et al



Comparison of two fluid-management strategies in
acute lung injury.


New
England Journal of Medicine 2006; 354: 2564-75.


OTHER
TOPICS


 


 


ECMO


 


 


CESAR 
– Wiedemann
HP et al



Efficacy and economic assessment of conventional
ventilatory support versus extracorporeal membrane
 oxygenation for severe adult respiratory failure
(CESAR): a multicentre randomised controlled trial.


N Engl J
Med. 2006 Jun 15;354(24):2564-75


 ANZ ECMO
 – Davies
A et al.



‘Extracorporeal Membrane Oxygenation for 2009
Influenza A(H1N1) Acute Respiratory Distress Syndrome’.


JAMA: The
Journal of the American Medical Association 302, no. 17 (4 November
2009): 1888–1895. doi:10.1001/jama.2009.1535.


PELE


 


 

Fan T et
al.



Prophylactic administration of parenteral steroids
for preventing airway complications after extubation in
adults:meta-analysis of randomised placebo controlled trials.

British
Medical Journal 2008; 337: 1088-91

Roberts RJ
eta l,



‘Corticosteroids for Prevention of
Postextubation Laryngeal Edema in Adults’.


The Annals
of Pharmacotherapy
 42, no. 5 (May 2008): 686–691. doi:10.1345/aph.1K655.


Markovitz
BP et al


.
‘Corticosteroids for the Prevention and Treatment of
Post Extubation Stridor in Neonates, Children and Adults’.


The
Cochrane Database of Systematic Reviews no. 2 (2008):
doi:10.1002/14651858.CD001000.pub2.


During
surgery


 


 


Severgnini
P et al.



‘Protective Mechanical Ventilation during General
Anesthesia for Open Abdominal Surgery Improves Postoperative Pulmonary
Function
’.



Anesthesiology 118, no. 6(June 2013): 1307–1321.
doi:10.1097/ALN.0b013e31829102de.


Weaning


 


 


Cochrane
review – Blackwood B et al.


Use of Weaning Protocols for Reducing Duration of
Mechanical Ventilation in Critically Ill Adult Patients: Cochrane
 Systematic Review and Meta-Analysis’.


BMJ:
British Medical Journal 342 (2011).


SPANISH
LUNG FAILURE GROUP
 – Esteban A et al


A Comparison of Four Methods of Weaning Patients
from Mechanical Ventilation’.


New
England Journal of Medicine
 332, no. 6 (1995): 345–350.

Upadya A
et al.



‘Fluid Balance and Weaning Outcomes’.


Intensive
Care Medicine
 31, no. 12 (29 September 2005): 1643–1647.
doi:10.1007/s00134-005-2801-3.

Burns KE
et al.



A meta-analysis of noninvasive weaning to facilitate
liberation from mechanical ventilation. 

Canadian
Journal of Anaesthesia 2006; 53: 305-15.

Cochrane
review 2013 – Burns KE et al.



‘Noninvasive Positive-Pressure Ventilation as a
Weaning Strategy for Intubated Adults with Respiratory Failure’.


The
Cochrane Database of Systematic Reviews
 12 (2013): CD004127.
doi:10.1002/14651858.CD004127.pub3.


NIV


 


 


GiViTI
 – Gristina
G et al.  (Italian Group for the Evaluation of Interventions in
Intensive Care Medicine).


Noninvasive
versus Invasive Ventilation for Acute Respiratory Failure in Patients
with Hematologic Malignancies: A 5-Year Multicenter Observational
Survey’
.


Critical
Care Medicine 39, no. 10 (October 2011): 2232–2239.
doi:10.1097/CCM.0b013e3182227a27.

Esteban A
et al.



Noninvasive positive-pressure ventilation for
respiratory failure after extubation
.

New
England Journal of Medicine 2004; 350: 2542-256.

Peter JV
et al.



Effect of non-invasive positive pressure ventilation
(NIPPV) on mortality in patients with acute cardiogenic pulmonary
oedema: a meta-analysis.

Lancet
2006; 367: 1155-63.



Tracheostomy


 


 


Blot F et
al.



Early tracheotomy versus prolonged endotracheal
intubation in unselected severely ill ICU patients
.


Intensive
Care Medicine 2008; 34: 1779-87


TRACMAN –
  Young D
et al.



‘Effect of Early vs Late Tracheostomy Placement on
Survival in Patients Receiving Mechanical Ventilation: The TracMan
Randomized Trial’.


JAMA: The
Journal of the American Medical Association 309, no. 20 (22 May 2013):
2121–2129. doi:10.1001/jama.2013.5154.


VAP


 


 


Heyland D
et al. (Canadian Critical Care Trials Group)



A randomized trial of diagnostic techniques for
ventilator-associated pneumonia.


New
England Journal of Medicine 2006; 355: 2619-30


Safdar N
et al.



Clinical and economic consequences of
ventilator-associated pneumonia: a systematic review.

Critical
Care Medicine 2005; 33: 2184-93.


Nitric


 


 


Adhikari
NK et al.



Effect of nitric oxide on
oxygenation and mortality in acute lung injury: systematic review and
meta-analysis


British
Medical Journal 2007; 334: 779-86

 Adhikari
NKJ et al.



‘Inhaled Nitric Oxide Does Not Reduce Mortality in
Patients with Acute Respiratory Distress Syndrome regardless of
Severity: Systematic Review and Meta-Analysis*’
.


Critical
Care Medicine
 42, no. 2 (February 2014): 404–412. doi:10.1097/CCM.0b013e3182a27909.


Sedation


 


 


ABC –
 Girard TD
et al.



Efficacy and safety of a paired sedation and
ventilator weaning protocol for mechanically ventilated patients
inintensive care (Awakening and Breathing Controlled trial): a
randomised controlled trial.


Lancet
2008; 371: 126-34.


Heliox


 


 

Colebourn
CL at al.



Use of helium-oxygen mixture in adult patients
presenting with exacerbations of asthma and chronic obstructive
pulmonary disease: a systematic review
.


Anaesthesia 2007; 62: 34-42.


TRALI


 


 

Marik,
Paul E., and Howard L. Corwin.



‘Acute Lung Injury Following Blood Transfusion:
Expanding the Definition:’


Critical
Care Medicine
 36, no. 11 (November 2008): 3080–3084.
doi:10.1097/CCM.0b013e31818c3801.

Hébert PC


‘A Multicenter, Randomized, Controlled Clinical
Trial of Transfusion Requirements in Critical Care
’.


New
England Journal of Medicine
 340, no. 6 (1999): 409–417.



Haematology patients


 


 


GiViTI 
– Gristina
GR et al (Italian Group for the Evaluation of Interventions in Intensive
Care Medicine).


Noninvasive
versus Invasive Ventilation for Acute Respiratory Failure in Patients
with Hematologic Malignancies: A 5-Year Multicenter Observational Survey
’.


Critical
Care Medicine 39, no. 10 (October 2011):
2232–2239. doi:10.1097/CCM.0b013e3182227a27.


 

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