↑ Return to Key papers

Renal key papers


ADQI – Bellomo R
Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technologyneeds: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.
Crit Care. 2004 Aug;8(4):R204-12. Epub 2004 May 24.
AKIN – Mehta R et al.
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury.
Crit Care. 2007;11(2):R31.
Lakhal K et al.
Acute Kidney Injury Network definition of contrast-induced nephropathy in the critically ill: incidence and outcome.
J Crit Care. 2011 Dec;26(6):593-9. doi: 10.1016/j.jcrc.2011.05.010. Epub 2011 Jul 6.

Renal support

Bouman C. et al.
‘Effects of Early High-Volume Continuous Venovenous Hemofiltration on Survival and Recovery of Renal Function in Intensive Care Patients with Acute Renal Failure: A Prospective, Randomized Trial’.
Critical Care Medicine 30, no. 10 (2002): 2205–2211.
DO-RE-MI – Kindgen-Milles D et al.
‘Study Protocol: The Dose Response Multicentre International Collaborative Initiative (DO-RE-MI)’.
Critical Care 9, no. 4 (2005): R396–R406.
HEMODIAFE –  Vinsonneau C et al.
‘Continuous Venovenous Haemodiafiltration versus Intermittent Haemodialysis for Acute Renal Failure in Patients with Multiple-Organ Dysfunction Syndrome: A Multicentre Randomised Trial’.
Lancet 368, no. 9533 (29 July 2006): 379–385. doi:10.1016/S0140-6736(06)69111-3
Schiffl H.
‘Renal Recovery from Acute Tubular Necrosis Requiring Renal Replacement Therapy: A Prospective Study in Critically Ill Patients’.
Nephrology Dialysis Transplantation 21, no. 5 (2006): 1248
John S and Eckardt KU
‘Renal Replacement Strategies in the ICU’.
Chest 132, no. 4 (October 2007): 1379–1388. doi:10.1378/chest.07-0167.
RENAL –  Bellomo R et al.
‘Intensity of continuous renal replacement in Critically Ill Patients’.
New England Journal of Medicine 359, no. 1 (July 2008): 7–20. doi:10.1056/NEJMoa0802639
VA/NIH (ARFTN) – Palevsky PM et al.
‘Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury’.
N Engl J Med 359, no. 1 (2008): 7–20. Wessex ICS BL review
Pannu NS et al.
‘Renal Replacement Therapy in Patients with Acute Renal Failure’.
JAMA: The Journal of the American Medical Association 299, no. 7 (2008): 793.
Tolwani AJ et al.
‘Standard versus High-Dose CVVHDF for ICU-Related Acute Renal Failure’.
Journal of the American Society of Nephrology 19, no. 6 (March 2008): 1233–1238. doi:10.1681/ASN.2007111173
Payen D et al.
‘Impact of Continuous Venovenous Hemofiltration on Organ Failure during the Early Phase of Severe Sepsis: A Randomized Controlled Trial*’.
Critical Care Medicine 37, no. 3 (March 2009): 803–810. doi:10.1097/CCM.0b013e3181962316.
IDEAL – Cooper BA et al. 
A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis. 
N Engl J Med 2010; 363:609-619
IVOIRE – Joannes-Boyau O et al.
‘High-Volume versus Standard-Volume Haemofiltration for Septic Shock Patients with Acute Kidney Injury (IVOIRE Study): A Multicentre Randomized Controlled Trial’.
Intensive Care Medicine 39, no. 9 (September 2013): 1535–46. doi:10.1007/s00134-013-2967-z.
CONVINT – Schefold JC et al.
The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): a prospective randomized controlled trial.
AKIKI group – Gaudry S et al.
Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit.

Diuretics and fluid balance

Bagshaw SM
Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis.
Crit Care Resusc. 2007 Mar;9(1):60–8.
Fluid balance, diuretic use, and mortality in acute kidney injury.
Clin J Am Soc Nephrol. 2011 May;6(5):966–73.
Payen D et al.
A positive fluid balance is associated with a worse outcome in patients with acute renal failure.
Crit Care. 2008;12(3):R74.
Bouchard J et al.
Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury.
Kidney Int. 2009 Aug;76(4):422–7.
SPARK protocol – Bagshaw SM et al.
The SPARK Study: a phase II randomized blinded controlled trial of the effect of furosemide in critically ill patients with early acute kidney injury.
Trials. 2010;11:50. 
Legrand M, Payen D.
Understanding urine output in critically ill patients.
Ann Intensive Care. 2011;1(1):13.
Teixeira C et al.
Fluid balance and urine volume are independent predictors of mortality in acute kidney injury.
Crit Care. 2013;17(1):R14.

Renal protection

Bellomo et al.
Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group
Lancet. 2000 Dec 23-30;356(9248):2139-43. BL Review
Chen HH et al.
‘Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure with Renal Dysfunction: The ROSE Acute Heart Failure Randomized Trial’.

Contrast injury

Tepel M et al.
Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine.
N Engl J Med. 2000 Jul 20;343(3):180-4.
Tepel M
Preventing nephropathy induced by contrast medium.
N Engl J Med. 2006 Jan 26;354(4):379-86
Solomon R et al.
Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents.
N Engl J Med. 1994 Nov 24;331(21):1416–20.
Marenzi G et al.
The prevention of radiocontrast-agent-induced nephropathy by hemofiltration.
N Engl J Med. 2003 Oct 2;349(14):1333–40.
Merten GJ et al.
Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.
JAMA. 2004 May 19;291(19):2328–34.
Marenzi G et al.
N-acetylcysteine and contrast-induced nephropathy in primary angioplasty.

Lakhal K et al.

Acute Kidney Injury Network definition of contrast-induced nephropathy in the critically ill: incidence and outcome.
J Crit Care. 2011 Dec;26(6):593-9. doi: 10.1016/j.jcrc.2011.05.010. Epub 2011 Jul 6.
Acetylcysteine for prevention of renal outcomes in patients undergoing coronary and peripheral vascular angiography: main results from the randomized Acetylcysteine for Contrast-induced nephropathy Trial (ACT).
Circulation. 2011 Sep 13;124(11):1250–9
PRESERVE protocol – Weisbord SD et al.
Prevention of contrast-induced AKI: a review of published trials and the design of the prevention of serious adverse events following angiography (PRESERVE) trial.
Clin J Am Soc Nephrol. 2013 Sep;8(9):1618–31.

Haem-related AKI - rhabdomyolysis

PICARD – Mehta RL et al.
Diuretics, mortality, and nonrecovery of renal function in acute renal failure.
Hatamizadeh P et al.
Epidemiologic aspects of the Bam earthquake in Iran: the nephrologic perspective.
Brown CVR et al.
Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference?
Mikkelsen TS and Toft P.
Prognostic value, kinetics and effect of CVVHDF on serum of the myoglobin and creatine kinase in critically ill patients with rhabdomyolysis.
Melli G et al.
Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine (Baltimore).

Leave a Reply

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>