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Neurology and sedation key papers

Stroke

 DESTINY – Jüttler E et al.
‘Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): A Randomized, Controlled Trial’.
Stroke; a Journal of Cerebral Circulation 38, no. 9 (September 2007): 2518–2525. doi:10.1161/STROKEAHA.107.485649.
 
Vahedi K et al.
‘Early Decompressive Surgery in Malignant Infarction of the Middle Cerebral Artery: A Pooled Analysis of Three Randomised Controlled Trials’.
Lancet Neurology 6, no. 3 (March 2007): 215–222. doi:10.1016/S1474-4422(07)70036-4.
 
DECIMAL – Vahedi K et al.
‘Sequential-Design, Multicenter, Randomized, Controlled Trial of Early Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction (DECIMAL Trial)’.
Stroke; a Journal of Cerebral Circulation 38, no. 9 (September 2007): 2506–2517. doi:10.1161/STROKEAHA.107.485235. 
 
INTERACT – Anderson CS et al.
Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial.
Lancet Neurol. 2008 May;7(5):391-9. doi: 10.1016/S1474-4422(08)70069-3.
 
HAMLET – Hofmeijer J et al.
‘Surgical Decompression for Space-Occupying Cerebral Infarction (the Hemicraniectomy After Middle Cerebral Artery Infarction with Life-Threatening Edema Trial [HAMLET]): A Multicentre, Open, Randomised Trial’.
Lancet Neurology 8, no. 4 (April 2009): 326–333. doi:10.1016/S1474-4422(09)70047-X.
 
ECASS III – Hacke W et al.
‘Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke’.
The New England Journal of Medicine 359, no. 13 (25 September 2008): 1317–1329. doi:10.1056/NEJMoa0804656. 
 
ATACH – Quereshi et al.
Antihypertensive treatment of acute cerebral haemorrhage.
Crit Care Med. 2010 Feb;38(2):637-48. doi: 10.1097/CCM.0b013e3181b9e1a5. 
 
Staykov, D., and R. Gupta.
‘Hemicraniectomy in Malignant Middle Cerebral Artery Infarction’.
Stroke 42, no. 2 (January 2011): 513–516. doi:10.1161/STROKEAHA.110.605642.
 
Jüttler E et al.
Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke.
N Engl J Med. 2014 Mar 20;370(12):1091–100. 

INTERACT II – Qureshi AI et al.
Interpretation and Implementation of Intensive Blood Pressure Reduction in Acute CerebralHemorrhage Trial (INTERACT II).
J Vasc Interv Neurol. 2014 Jun;7(2):34-40.

Berkhemer OA et al.
A randomized trial of intraarterial treatment for acute ischemic stroke.
DESTINY 2 – Jüttler E et al.
Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke.
PATCH – Baharoglu MI et al.
Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial.

Delirium

Aldemir M et al.
‘Predisposing Factors for Delirium in the Surgical Intensive Care Unit’.
Critical Care 5, no. 5 (2001): 265.
 
Ely WE et al.
‘Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit’.
Jama 291, no. 14 (2004): 1753–1762.
 
Micek S et al.
‘Delirium as Detected by the CAM-ICU Predicts Restraint Use among Mechanically Ventilated Medical Patients*:
Critical Care Medicine 33, no. 6 (June 2005): 1260–1265. doi:10.1097/01.CCM.0000164540.58515.BF.
 
Pandharipande PP et al.
‘Delirium: Acute Cognitive Dysfunction in the Critically Ill’.
Current Opinion in Critical Care 11, no. 4 (2005): 360–368.
 
Pandharipande PP et al.
‘Lorazepam Is an Independent Risk Factor for Transitioning to Delirium in Intensive Care Unit Patients’.
Anesthesiology 104, no. 1 (2006): 21.
 
MENDS – Pandharipande PP et al.
‘Effect of Sedation with Dexmedetomidine vs Lorazepam on Acute Brain Dysfunction in Mechanically Ventilated Patients: The MENDS Randomized Controlled Trial’.
JAMA: The Journal of the American Medical Association 298, no. 22 (12 December 2007): 2644–2653. doi:10.1001/jama.298.22.2644.
 
Pisani ME et al.
‘Benzodiazepine and Opioid Use and the Duration of Intensive Care Unit Delirium in an Older Population*:’
Critical Care Medicine 37, no. 1 (January 2009): 177–183. doi:10.1097/CCM.0b013e318192fcf9.
 
Morandi A et al.
‘Sedation, Delirium and Mechanical Ventilation: The “ABCDE” Approach:’
Current Opinion in Critical Care 17, no. 1 (February 2011): 43–49. doi:10.1097/MCC.0b013e3283427243.
 
SLEAP – Mehta S et al.
‘Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for with a Sedation Protocol: A Randomized Controlled Trial’.
JAMA: The Journal of the American Medical Association 308, no. 19 (21 November 2012): 1985–1992.
 
Pandharipande PP et al.
‘Long-Term Cognitive Impairment after Critical Illness’.
The New England Journal of Medicine 369, no. 14 (3 October 2013): 1306–1316. doi:10.1056/NEJMoa1301372.
 
Page VJ et al.
Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial.
 
Patel SB et al.
‘Rapidly Reversible, Sedation-Related Delirium versus Persistent Delirium in the ICU’.
American Journal of Respiratory and Critical Care Medicine (14 January 2014). doi:10.1164/rccm.201310-1815OC.
 
Morandi A et al.
Statins and delirium during critical illness: a multicenter, prospective cohort study*.

Chen K et al.
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.
Cochrane Database Syst Rev. 2015 Jan 6;1:CD010269. doi: 10.1002/14651858.CD010269.pub2.

Salluh JI et al.
Outcome of delirium in critically ill patients: systematic review and meta-analysis.
BMJ. 2015 Jun 3;350:h2538. doi: 10.1136/bmj.h2538.

Sedation

Kress et al.
‘Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation’.
The New England Journal of Medicine 342, no. 20 (18 May 2000): 1471–1477. doi:10.1056/NEJM200005183422002.
 
MENDS – Pandharipande PP et al.
‘Effect of Sedation with Dexmedetomidine vs Lorazepam on Acute Brain Dysfunction in Mechanically Ventilated Patients: The MENDS Randomized Controlled Trial’.
JAMA: The Journal of the American Medical Association 298, no. 22 (12 December 2007): 2644–2653. doi:10.1001/jama.298.22.2644. 
 
ABC – Girard TD et al.
‘Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol for Mechanically Ventilated Patients in Intensive Care (Awakening and Breathing Controlled Trial): A Randomised Controlled Trial’.
Lancet 371, no. 9607 (12 January 2008): 126–134. doi:10.1016/S0140-6736(08)60105-1.
 
KETASED – Jabre P et al.
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Lancet. 2009 Jul 25;374(9686):293–300.WessexICS BL review
 
Strøm T et al.
A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial.
 
Augustes R and Ho KM.
‘Meta-Analysis of Randomised Controlled Trials on Daily Sedation Interruption for Critically Ill Adult Patients’.
Anaesthesia and Intensive Care 39, no. 3 (May 2011): 401–409. 
 
MIDEX/PRODEX –  Jakob SM et al.
‘Dexmedetomidine vs Midazolam or Propofol for Sedation during Prolonged Mechanical Ventilation: Two Randomized Controlled Trials’.
JAMA: The Journal of the American Medical Association 307, no. 11 (21 March 2012): 1151–1160. doi:10.1001/jama.2012.304.
 
SLEAP – Mehta S et al.
‘Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for with a Sedation Protocol: A Randomized Controlled Trial’.
JAMA: The Journal of the American Medical Association 308, no. 19 (21 November 2012): 1985–1992.
 
Shehabi Y et al.
‘Early Intensive Care Sedation Predicts Long-Term Mortality in Ventilated Critically Ill Patients’.

Traumatic brain injury

Bulger EM et al.
‘Out-of-Hospital Hypertonic Resuscitation Following Severe Traumatic Brain Injury: A Randomized Controlled Trial’.
JAMA: The Journal of the American Medical Association 304, no. 13 (6 October 2010): 1455–1464. doi:10.1001/jama.2010.1405.
 
BEST:TRIP – Chesnut R et al.
‘A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury’.
The New England Journal of Medicine 367, no. 26 (27 December 2012): 2471–2481. doi:10.1056/NEJMoa1207363
 
DECRA – Cooper JD et al.
‘Decompressive Craniectomy in Diffuse Traumatic Brain Injury’. 

RESCUE-ICP (underway) Hutchinson PJ et al.
Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com).
Acta Neurochir Suppl. 2006;96:17-20.

Subarachnoid haemorrhage

Pickard JD et al.
Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial.
BMJ. 1989 Mar 11;298(6674):636–42.
 
ISAT – Molyneux A et al.
International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial.
Lancet. 2002 Oct 26;360(9342):1267–74.
 
Van der Schaaf I et al.
Endovascular coiling versus neurosurgical clipping for patients with aneurysmal subarachnoid haemorrhage.
Cochrane Database Syst Rev. 2005;(4):CD003085.
 
MASH – Van den Bergh WM et al.
Magnesium sulfate in aneurysmal subarachnoid hemorrhage: a randomized controlled trial.
Stroke. 2005 May;36(5):1011–5. 
 
ISAT update – Sellar R & ISAT Collaborative Group.
ISAT: The International Subarachnoid Aneurysm Trail. Lessons and Update.
Interv Neuroradiol. 2008 Sep 1;14 Suppl 1:50–1. 
 
IMASH – Wong GKC et al.
Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage (IMASH): a randomized, double-blinded, placebo-controlled, multicenter phase III trial.
Stroke. 2010 May;41(5):921–6.
 
MASH – 2 – Dorhout Mees SM et al.
Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial.
Lancet. 2012 Jul 7;380(9836):44–9.
INTERACT2 – Anderson CS et al.
Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage.
 
Reddy D et al.
Prophylactic Magnesium Sulfate for Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis.
Neurocrit Care. 2014 Mar 12; 
ATACH-2 Qureshi AI et al.
Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. New England Journal of Medicine [Internet]. 2016 Jun 8

Outcome prediction post arrest

Fugate JE et al.
The FOUR score predicts outcome in patients after cardiac arrest.
Neurocrit Care. 2010 Oct;13(2):205–10.
 
Golan E et al.
Predicting Neurologic Outcome After Targeted Temperature Management for Cardiac Arrest: Systematic Review and Meta-Analysis.
Crit Care Med. 2014 Apr 8;
 
Oddo M and Rossetti AO.
Early multimodal outcome prediction after cardiac arrest in patients treated with hypothermia.
Crit Care Med. 2014 Jun;42(6):1340–7.

Guillain-Barre syndrome

PES-BGS trials group
‘Randomised Trial of Plasma Exchange, Intravenous Immunoglobulin, and Combined Treatments in Guillain-Barré Syndrome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group’.
Lancet 349, no. 9047 (25 January 1997): 225–230.

Psychological sequelae

ARDSNET follow-up – Mikkelsen ME et al.
The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury.
Am J Respir Crit Care Med. 2012 Jun 15;185(12):1307–15. 
 
BRAIN-ICU – Pandharipande PP et al.
‘Long-Term Cognitive Impairment after Critical Illness’.
The New England Journal of Medicine 369, no. 14 (3 October 2013): 1306–1316. doi:10.1056/NEJMoa1301372. 

Sleep

Matthews EE.
Sleep disturbances and fatigue in critically ill patients.

Hu R et al. Cochrane review
Non-drug treatments promoting sleep in the ICU
Cochrane reviews 6th October 2015

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