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Haematology and haemorrhage key papers

Thromboprophylaxis

Gallus AS et al.
Small subcutaneous doses of heparin in prevention of venous thrombosis.
 
Cade JF.
High risk of the critically ill for venous thromboembolism.
Crit Care Med. 1982 Jul;10(7):448–50.
 
Fraisse F et al.
Nadroparin in the prevention of deep vein thrombosis in acute decompensated COPD. The Association of Non-University Affiliated Intensive Care Specialist Physicians of France.
 
Cook DJ, Crowther MA.
Thromboprophylaxis in the intensive care unit: focus on medical-surgical patients.
Crit Care Med. 2010 Feb;38(2 Suppl):S76–82.
 
Alikhan R et al.
‘Heparin for the Prevention of Venous Thromboembolism in Acutely Ill Medical Patients (excluding Stroke and Myocardial Infarction)’.
The Cochrane Database of Systematic Reviews 5 (7 May 2014): CD003747. doi:10.1002/14651858.CD003747.pub4.

Reversing anticoagulants

Eerenberg ES et al.
Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects.
Circulation. 2011 Oct 4;124(14):1573-9. doi: 10.1161/CIRCULATIONAHA.111.029017. Epub 2011 Sep 6.

Transfusion

For haemorrhage in trauma see Trauma Key Papers

TRICC – Hébert PC et al.
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
New England Journal of Medicine. 1999;340(6):409–17.
 
TRICC CVS disease – Hébert PC  et al.
Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases?
Crit Care Med. 2001 Feb;29(2):227–34.
 
TRICC trauma – McIntyre L  et al.
Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?
J Trauma. 2004 Sep;57(3):563–568; discussion 568.
 
TRICC head injury – McIntyre LA et al.
Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury.
Neurocrit Care. 2006;5(1):4–9.
 
TRISS – Holst LB et al.
Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock.
Lacroix J et al.
Age of transfused blood in critically ill adults.

Platelets

Stanworth SJ et al.
Prophylactic platelet transfusion for haemorrhage after chemotherapy and stem cell transplantation.

Cochrane Database Syst Rev. 2004;(4):CD004269.

Slichter SJ et al.

Dose of prophylactic platelet transfusions and prevention of hemorrhage.
N Engl J Med. 2010 Feb 18;362(7):600–13.
 
Stanworth SJ et al.
A no-prophylaxis platelet-transfusion strategy for hematologic cancers.
N Engl J Med. 2013 May 9;368(19):1771–80. 

Transfusion-associated lung injury

Marik PE, Corwin HL.
Acute lung injury following blood transfusion: Expanding the definition.
Critical Care Medicine. 2008 Nov;36(11):3080–4.

Erythropoietin

Shermock KM et al.
Erythropoietic agents for anemia of critical illness.
Am J Health Syst Pharm. 2008 Mar 15;65(6):540–6.
 
Mesgarpour B et al.
‘Safety of off-Label Erythropoiesis Stimulating Agents in Critically Ill Patients: A Meta-Analysis’.

Antifibrinolytics

Mangano DT et al.
Multicenter Study of Perioperative Ischemia Research Group, Ischemia Research and Education Foundation. The risk associated with aprotinin in cardiac surgery.
N Engl J Med. 2006 Jan 26;354(4):353–65
 
CRASH-2  Shakur H et al.
‘Effects of Tranexamic Acid on Death, Vascular Occlusive Events, and Blood Transfusion in Trauma Patients with Significant Haemorrhage (CRASH-2): A Randomised, Placebo-Controlled Trial’.
Lancet 376, no. 9734 (3 July 2010): 23–32. doi:10.1016/S0140-6736(10)60835-5. 
 
MATTERs – Morrison JJ et al.
Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs)
Study. Arch Surg. 2012 Feb;147(2):113–9. 
 
Wardrop D et al.
Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders.
Cochrane Database Syst Rev. 2013;7:CD009733. 

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