Key papers

  1. Sepsis and infection

  2. Cardiac and monitoring

  3. Respiratory and airway

  4. Neurological and sedation

  5. Gastrointestinal and nutrition

  6. Renal

  7. Metabolic and endocrine

  8. Haematology and haemorrhage

  9. Trauma and burns

  10. Imaging and echocardiography

  11. Pre and post-ICU

  12. Ethics and management


Cardiovascular and monitoring key papers

Inotropes and pressors in septic shock See Sepsis and infection Steroids in septic shock See Sepsis and infection

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Gastrointestinal and nutrition key papers

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Governance and ethics key papers


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Haematology and haemorrhage key papers

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Hit parade 2013

Intracranial haemorrhage INTERACT2 – Anderson CS, et al.‘Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage’. New England Journal of Medicine 368, no. 25 (20 June 2013): 2355–2365. doi:10.1056/NEJMoa1214609. Hypovolaemic shock CRISTAL – Annane, Djillali et al. ‘Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock: The CRISTAL …

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Imaging and echocardiography key papers

Echocardiography Ultrasound CT    

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Metabolic and endocrine key papers

Glucose control CGAO-REA – Kalfon P et al. ‘Tight Computerized versus Conventional Glucose Control in the ICU: A Randomized Controlled Trial’. Intensive Care Medicine 40, no. 2 (February 2014): 171–181. doi:10.1007/s00134-013-3189-0.   Van den Berghe G. ‘Intensive Insulin Therapy in Critically Ill Patients’. The New England Journal of Medicine 345, no. 19 (8 November 2001): …

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Neurology and sedation key papers

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Obstetrics key papers

Overviews and perspective ICNARC Female admissions (aged 16-50 years) to adult, general critical care units in England, Wales and Northern Ireland, reported as “currently pregnant” or “recently pregnant” ICNARC report 2009 Φ   Neligan PH, and Laffey JG. ‘Clinical Review: Special Populations–Critical Illness and Pregnancy’. Critical Care (London, England) 15, no. 4 (2011): 227. doi:10.1186/cc10256.Φ Plaat …

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Pre and post ICU key papers

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Renal key papers

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Resp table

  ARDS     Ventilation Strategy     Eichacker P et al. Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes. American Journal of Respiratory and Critical Care Medicine 2002 166: 1510-4 Needham D et al. ‘Lung Protective Mechanical Ventilation and Two Year Survival in Patients with Acute Lung Injury: Prospective Cohort …

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Respiratory and airway key papers

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Sepsis and infection key papers

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Trauma and burns key papers

Trauma Bickell WH et al. ‘Immediate versus Delayed Fluid Resuscitation for Hypotensive Patients with Penetrating Torso Injuries’. The New England Journal of Medicine 331, no. 17 (27 October 1994): 1105–1109. doi:10.1056/NEJM199410273311701.   CRASH – Roberts I et al.‘ Effect of Intravenous Corticosteroids on Death within 14 Days in 10008 Adults with Clinically Significant Head Injury (MRC CRASH Trial): …

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