Be balanced when resuscitating sepsis?

Raghunathan has used some interesting statistics to try and extract the effects of using Saline or Ringer’s lactate in resuscitating sepsis. Elixhauser comborbidities, 5:1 greedy matching, Generalized Estimating Equation models, and “missing-ness” are just a few of the terms I didn’t understand.

Nevertheless this appears to be a retrospective study that suggests there’s measurable mortality benefit in using balanced resuscitation fluid in the septic adult. The greater the proportion of balanced fluid the better they did.

Hypothesis generated!